SEMBLE Raises €35 Million to Build Healthcare’s Operating System

Over the past twenty years, enterprise digital transformation has been built around two major software infrastructures. ERP systems structured internal operations. CRM platforms centralized customer relationships. In healthcare, a new category of platforms is now emerging: Care Operating Systems, systems capable of orchestrating the entire care journey, from medical data and administrative workflows to future AI agents.

This evolution sits at the core of Semble’s strategy. The European healthcare software company, specializing in care management and coordination, has announced a €35 million funding round led by Revaia, with participation from Partech and continued support from Mercia Ventures and Octopus Ventures.

The transaction comes at a time when European healthcare systems are undergoing profound transformation. Demographic ageing, workforce shortages, the explosion of medical data, and the rise of artificial intelligence are forcing healthcare organizations to rethink how they operate.

Fragmentation has become the primary challenge

Over the past two decades, healthcare digitization has been built layer by layer. One application for appointments. Another for medical records. A third for billing. Additional tools for telemedicine, prescriptions, care coordination, and patient communications.

While this accumulation of solutions has modernized many processes, it has also created a new challenge: fragmentation.

“For years, the industry has tried to solve complex systemic problems through point solutions, but fragmented technology often adds operational complexity for healthcare professionals while creating a disconnected experience for patients,” says Christoph Lippuner, Co-Founder and CEO of Semble.

The challenge is therefore no longer simply to digitize healthcare, but to connect all the stakeholders, data sources, and tools that make up the patient journey.

Building the operating system for healthcare

This is precisely the layer where Semble aims to position itself. The company has developed a unified platform designed for independent practitioners, medical centers, and healthcare organizations. Its software coordinates clinical data, administrative tasks, information flows, and interactions between different stakeholders.

With more than 10 million patients treated through its platform, Semble now serves over 1,700 healthcare organizations and nearly 16,000 daily users. The platform also integrates with more than 1,200 third-party solutions spanning the healthcare ecosystem, from appointment booking and diagnostics to billing and patient engagement.

This openness is a central component of the company’s strategy.

“The healthcare organizations that succeed over the next decade will be those built on open and interoperable systems capable of connecting data, professionals, and care pathways within a unified patient experience,” says Christoph Lippuner.

For Morgan Kessous, Partner at Revaia, the opportunity extends far beyond traditional healthcare software:

“Semble is building the operating system for modern healthcare: a platform that combines deep clinical capabilities, large-scale deployment capacity, and the trust of healthcare professionals.”

A European race is underway

Semble is not alone in pursuing this vision. In the United States, Epic Systems and Athenahealth already occupy strategic positions within hospital and physician-office infrastructure. Oracle has pursued the same ambition since acquiring Cerner for nearly $28 billion.

In Europe, the landscape remains more fragmented. Doctolib continues to expand beyond appointment scheduling to become a broader patient journey platform. In Germany, CompuGroup Medical maintains a dominant position among healthcare professionals. In the United Kingdom, Accurx has emerged as a key player in practitioner-patient coordination.

Yet competition no longer comes solely from established software vendors. A new generation of AI-native companies such as Nabla, Corti, and Tortus is attempting to become the primary interface used by healthcare professionals. Their objective is not necessarily to replace existing software platforms, but to sit on top of them, automating an increasing share of administrative and clinical work.

Control of the patient journey is therefore becoming a strategic battleground, comparable to the role ERP systems played in manufacturing or CRM platforms in commercial organizations.

France as a new growth market

France occupies a special place in Semble’s expansion strategy. The market is undergoing rapid transformation, driven by the growth of multidisciplinary health centers, medical groups, and private healthcare networks. More than 200,000 physicians are seeing their practice models evolve toward collaborative structures that require more advanced coordination tools.

Semble has opened offices in Paris and Toulouse and says it has tripled its French headcount since December 2024. The company has also secured LAP HAS v2 and Ségur V1 certifications in less than a year, two critical requirements for operating at scale in the French healthcare market.

“Semble has built the infrastructure needed to orchestrate patient journeys across increasingly complex and highly regulated healthcare systems,” says Rémi Said, General Partner at Partech.

AI could accelerate market consolidation

The arrival of artificial intelligence further increases the strategic value of these platforms. Companies that already control data, workflows, and interactions between healthcare professionals hold a significant advantage when deploying assistants capable of drafting clinical notes, coordinating care pathways, preparing consultations, or automating administrative tasks.

Semble plans to use the new funding to accelerate the development of its care orchestration capabilities and AI-powered solutions.

More broadly, the emergence of Care Operating Systems may represent for healthcare what ERP systems became for industry and CRM platforms became for sales organizations: the foundational software layer upon which the next generation of AI applications will be built. The question is no longer who digitizes healthcare, but who controls the infrastructure through which care is delivered.